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On voxel-by-voxel accumulated dose for prostate radiation therapy using deformable image registration.

机译:使用可变形图像配准进行前列腺放射治疗的体素逐体素累积剂量。

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摘要

Since delivered dose is rarely the same with planned, we calculated the delivered total dose to ten prostate radiotherapy patients treated with rectal balloons using deformable dose accumulation (DDA) and compared it with the planned dose. The patients were treated with TomoTherapy using two rectal balloon designs: five patients had the Radiadyne balloon (balloon A), and five patients had the EZ-EM balloon (balloon B). Prostate and rectal wall contours were outlined on each pre-treatment MVCT for all patients. Delivered fractional doses were calculated using the MVCT taken immediately prior to delivery. Dose grids were accumulated to the last MVCT using DDA tools in Pinnacle3 TM (v9.100, Philips Radiation Oncology Systems, Fitchburg, USA). Delivered total doses were compared with planned doses using prostate and rectal wall DVHs. The rectal NTCP was calculated based on total delivered and planned doses for all patients using the Lyman model. For 8/10 patients, the rectal wall NTCP calculated using the delivered total dose was less than planned, with seven patients showing a decrease of more than 5% in NTCP. For 2/10 patients studied, the rectal wall NTCP calculated using total delivered dose was 2% higher than planned. This study indicates that for patients receiving hypofractionated radiotherapy for prostate cancer with a rectal balloon, total delivered doses to prostate is similar with planned while delivered dose to rectal walls may be significantly different from planned doses. 8/10 patients show significant correlation between rectal balloon anterior-posterior positions and some VD values.
机译:由于输送的剂量很少与计划的相同,因此我们使用可变形剂量累积(DDA)计算了经直肠球囊治疗的10例前列腺放射治疗患者的输送的总剂量,并将其与计划的剂量进行了比较。使用两种直肠球囊设计对患者进行了TomoTherapy治疗:五名患者使用了Radiadyne气球(气球A),五名患者使用了EZ-EM气球(气球B)。在所有患者的每个治疗前MVCT上都概述了前列腺和直肠壁轮廓。使用分娩前立即服用的MVCT计算分次剂量。使用Pinnacle3TM(v9.100,飞利浦放射肿瘤系统,美国菲奇堡,美国)中的DDA工具将剂量栅格累积到最后的MVCT。使用前列腺和直肠壁DVH将提供的总剂量与计划的剂量进行比较。使用莱曼模型,根据所有患者的总输送剂量和计划剂量计算直肠NTCP。对于8/10例患者,使用输送的总剂量计算出的直肠壁NTCP少于计划,其中7例患者的NTCP减少超过5%。对于研究的2/10例患者,使用总输送剂量计算的直肠壁NTCP比计划高2%。这项研究表明,对于使用直肠球囊进行前列腺癌的超分割放射治疗的患者,前列腺的总递送剂量与计划的相似,而直肠壁的递送剂量可能与计划的剂量明显不同。 8/10位患者显示直肠球囊前后位置与某些VD值之间存在显着相关性。

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